Add all of the burger ingredients to a large mixing bowl. Using clean hands mix and mash everything together until evenly combined.
2 lbs lean ground beef, 1 small yellow onion, 1 tbsp minced garlic, 2 1/2 tbsp worcestershire sauce, 1 large egg, 1/2 cup Italian bread crumbs, 1/4 cup ketchup, 2 dashes hot sauce, 1 tsp salt, 1 tsp pepper, 1 tsp onion powder, 1 tsp garlic powder, 1 tsp ground oregano, 1 tsp smoked paprika